Raav2tyf-cb-hrs1
WebSafety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin. Hum Gene Ther Clin Dev. Sep;26(3):165-76. PMID: 26390090; AAV2(Y-F+T-V) WebX-Linked Retinoshisis (RS1) Gene Therapy Trial. A Multiple-Site, Phase 1/2, Safety and Efficacy Trial of a Recombinant Adenoassociated Virus Vector Expressing Retinoschisin (rAAV2tYF-CB-hRS1) in Patients With X-linked Retinoschisis. The purpose of this study is to learn about a new gene therapy that may help patients with X-Linked Retinoschisis ...
Raav2tyf-cb-hrs1
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WebMar 1, 2024 · Recently, an instructive paper was published detailing the 12-month results from intravitreal injections of AAV (rAAV2tYF-CB-hRS1) for patients with X-linked retinoschisis. 5 Therein, the authors highlight that their gene augmentation strategy did not demonstrate a measurable improvement for patients as investigated with visual acuity, … WebMar 4, 2024 · March 4, 2024. Biogen has agreed to acquire Nightstar Therapeutics for approximately $877 million, the companies said today, in a deal that replenishes the buyer’s ophthalmology drug pipeline ...
WebAug 25, 2015 · We report here results of a study evaluating the safety and biodistribution of rAAV2tYF-CB-hRS1 in RS1-deficient mice. Three groups of male RS1-deficient mice received an intravitreal injection in one eye of either vehicle, or rAAV2tYF-CB-hRS1 at one of two dose levels (1 × 10 9 or 4 × 10 9 vg/eye) and were sacrificed 30 or 90 days later. WebN2 - Purpose: To evaluate the safety and efficacy of rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus vector expressing retinoschisin (RS1), in individuals with retinal …
WebNov 18, 2024 · Ye GJ, Budzynski E, Sonnentag P et al. Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin. Hum. Gene Ther. Clin. Dev. 2015; 26(3), 165–176. WebDec 1, 2024 · The rAAV2tYF-CB-hRS1 trial remains ongoing through 5 years of follow-up to assess long-term safety, and insights gained from the initial treatment and 12-month …
WebrAAV2tYF-CB-hRS1 administered by intravitreal injection in one eye in individuals with XLRS. The primary objective is to evaluate safety and the secondary objective is to evaluate …
WebApr 26, 2024 · (rAAV2tYF-GRK1-RPGR) Applied Genetic Technologies Corp NCT03316560 Choroideremia REP1 I/II 14 Oct-2011 Oct-2024 rAAV2.REP1 University of Oxford NCT01461213 [14] ... I/II 27 May-2015 Oct-2024 rAAV2tYF-CB-hRS1 Applied Genetic Technologies Corp NCT02416622 RPE65: Retinal pigmented epithelium-specific protein … chinese restaurants in menifee caWebWe report here results of a study evaluating the safety and biodistribution of rAAV2tYF-CB-hRS1 in RS1-deficient mice. Three groups of male RS1-deficient mice received an … chinese restaurants in mckinney texasWebMay 18, 2015 · Results demonstrated that intravitreal injection of rAAV2tYF-CB-hRS1 was well tolerated with minimal ocular inflammatory cells detected by histopathology. RS1 expression, measured by immunohistochemistry, was associated with decreased severity of splitting and disorganization of the inner nuclear layer of the retina at the higher dose … chinese restaurants in melkshamWebMay 1, 2015 · rAAV2tYF-CB-hRS1 in Nonhuman Primates Guo-jie Y e, 1 Ewa Budzynski, 2 Peter Sonnentag, 2 Paul Miller, 3 Alok K. Sharma, 2 James Hoeve, 3 Kenneth S. Latimer, 2 Kellie Howard, 4 chinese restaurants in menominee miWebDec 1, 2024 · The IVT administration of rAAV2tYF-CB-hRS1 was generally safe at each of the dose levels. There were no AEs resulting in early termination, and no dose-limiting … grand the auto 5 torrentWebIntravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in X-linked Retinoschisis - 1 Year Clinical Results. (PubMed, Ophthalmol Retina) - "Gene … chinese restaurants in meridian mississippiWebDec 14, 2024 · The phase 1/2 study investigated rAAV2tYF-CB-hRS1 in patients with XLRS due to mutations in the RS1 gene which provides instructions for the production of the protein called retinoschisin and is found in the retina. After six months of treatment, the drug was generally safe and well-tolerated but did not show any signs of clinical activity. grand theatre wolverhampton seats