Plectin网蛋白

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August undefined, 2024

Webb12 nov. 2024 · 经蛋白组学分析，靶向肽PTP是通过与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用的。然而，胰腺癌在遗传上是非常复杂的，肿瘤的质量是由患者的63个基因改变和12个核心信号通路的异常引起的，在不同癌症患者的肿瘤生物标志物表达中存在异质性。 Webb9 juni 2013 · Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a cytoskeletal crosslinker and signaling scaffold, affecting mechanical as well as dynamic properties of the cytoskeleton. As a member of the plakin family of cytolinker proteins, plectin has a multidomain structure that is responsible for its vast binding …

Plectin-1 (D6A11) Rabbit mAb Cell Signaling Technology

Webb21 mars 2024 · PLEC (Plectin) is a Protein Coding gene. Diseases associated with PLEC include Epidermolysis Bullosa Simplex 5A, Ogna Type and Muscular Dystrophy, Limb … Webb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element … ecology auto parts santa fe springs

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Webb14 okt. 2008 · Description. A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS5C is an autosomal recessive disorder characterized by severe skin blistering at birth and congenital pyloric atresia. Death … Webb病理结果：苏木精-伊红染色可见核链，肌核聚集；抗-plectin免疫组织化学染色可见plectin蛋白在肌浆中聚集。 PLEC基因突变所致的肢带型肌营养不良2Q型报道较少，本研究新发1例因 PLEC 基因c.6428C>T和c.13192G>A复合杂合错义突变所致的肢带型肌营养不良2Q型，扩展了 PLEC 基因的突变谱，也加深临床医师对该 ... WebbPlectin基因敲除抑制了每个器官的转移数量，并降低了整体转移负担。为了深入了解plectin在前列腺癌生长和转移中的作用，研究人员对前列腺癌plectin敲除异种移植组织进行了蛋白质组学分析。基因集富集分析表明，与细胞外基质和层粘连蛋白相互作用有关的蛋白质水平增加，而调节氨基酸代谢、细胞骨架蛋白和细胞应激反应蛋白质水平下降。 … computers kelmscott

PTP peptide-PEG-DSPE 胰腺癌靶向肽（PTP）-德尔塔(Delta)生物 …

Plectin抗体 (GTX130764) GeneTex中国官方网站

WebbPlectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in … Webb使用 Plectin-1 (D6A11) Rabbit mAb（泳道 2）或 Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900（泳道 3）对 U-2 OS 细胞提取物网蛋白-1 进行免疫沉淀。泳道 1 是 10% 输 … computers kempseyWebbAn in situ proximity ligation assay confirmed that FUS-plectin interactions take place in the cytoplasm of cells. Furthermore, plectin deficient cells showed an altered subcellular localization of FUS and a deregulated expression of mRNAs bound to FUS. Our results show that plectin is important for normal FUS localization and function. computers katoomba

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Plectin网蛋白

plectin in Chinese - plectin meaning in Chinese - plectin Chinese …

WebbPlectin. Plectin, also referred to as IFAP 300 or HD1, is a 500-kDa plakin family member. It is particularly important for hemidesmosome function in epithelial tissues, and as a cytoplasmic cytoskeletal linker in other tissues, but has also been reported in less abundance in desmosomes. Plectin׳s importance for hemidesmosome stability and ... Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by …

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Webb15 sep. 2013 · Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IF … Webb除原位胰腺组织外，Plectin-1在转移性病变包括肝脏、淋巴结和腹膜组织的免疫组化研究中均有显着表达。通过上述研究说明，Plectin-1的表达特点和表达量可用于鉴别胰腺的良恶性病变，可成为特殊的生物标记。

Webbplectin binding antibodies antibodies binding Prior art date 2016-04-08 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a … Webb5 feb. 2024 · These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms.

Webbplectin 定义细胞质基质中含量丰富的一种蛋白质（300 kDa）。与多种中间丝共存，与中间丝、微管和肌球蛋白粗丝的交联和锚定有关。应用学科细胞生物学（一级学科），细胞 … WebbPlektin (engl.Plectin, kurz PCN oder PLTN), auch Plectin-1 oder Hemidesmosomal protein 1 (HD1), ist ein bei Eukaryoten vorkommendes Protein.Es lässt sich im Zytoplasma nahezu aller eukaryotischen Zellen nachweisen, in großen Mengen jedoch vor allem in Muskel- und Herzmuskelzellen, Hautzellen, Nervenzellen sowie in Zellen der Plazenta. . Plektin ist ein …

Webb20 nov. 2024 · As plectin is a critical regulator for cell cytoarchitecture and motility, we next measured the effects of plectin knock-down on prostate cancer invasion and migration.

Webb16 maj 2024 · 2024年5月16日讯/生物谷BIOON/---选择性剪接（alternative splicing）是一种转录后调控机制，对转录组和蛋白质组的多样性至关重要。通过增加蛋白水平的复杂性，选择性剪接可以引起细胞的功能变化。众所周知，RNA结构元件在转录后调控过程（包括选择性剪接）中起着关键作用。因此，由RNA二级结构编码的调节信息对选择性剪接决定的 … computers kellsWebb5 mars 2024 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell … computer sketch tumblrWebb1 sep. 1998 · Plectin and its isoforms are versatile cytoskeletal linker proteins of very large size (>500 kDa) that are abundantly expressed in a wide variety of mammalian tissues and cell types. Earlier studies indicated that plectin molecules were associated with and/or directly bound to subcomponents of all three major cytoskeletal filament networks, the … ecology auto wreckers san diego ecology auto wrecking la miradaWebbThe cytolinker protein plectin anchors IF networks to junctional complexes, the nuclear envelope and cytoplasmic organelles and it mediates their cross talk with the actin and tubulin cytoskel-eton. These functions empower plectin to wield significant influence over IF network cytoarchitecture. Moreover, the unusual diversity of plectin isoforms ecology auto wrecking chula vista caWebb27 feb. 2024 · Plectin is a giant cytoskeletal crosslinker (also known as a cytolinker) protein of more than 4,500 amino acids. It belongs to the plakin family of giant proteins, including desmoplakin, envoplakin and periplakin. Plectin was first described in 1980 as a polypeptide component that co-purified with the intermediate filament protein vimentin … computer skill level chartWebb30 juni 2024 · 存储条件-20℃以下冰冻、干燥、避光。长期保存惰性（氩气或者氮气）保护。产品化学性质PTP-PEG-DSPE磷脂-聚乙二醇-胰腺癌靶向肽PTP与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用。本产品仅用于研究和制造用途，不能用于人类或诊断用途。 ecology bbc bitesize aqa