Drimanes
Web13 apr 2024 · Natural drimanes and coloratanes, as well as their semi-synthetic derivatives, showed promising results against cancer cell lines with in vitro activities in the low micro- … Web1 apr 2014 · Strain MF347 produced also the known spirocyclic drimanes stachybocin A (12) and stachybocin B (11) featured by two sesquiterpene-spirobenzofuran structural units connected by a lysine residue; ...
Drimanes
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Web6 giu 2011 · β-Selinene (97) is the major sesquiterpene hydrocarbon of calamondin orange (Citrofortunella mitis) fruits.The bicyclic skeleton can be formed by cyclization of FPP (1) to the eudesmane cation (78) by way of germacrene A (77) (Scheme 48).Although no studies of this mechanism have as yet been reported, β-selinene synthase has been purified … WebCovering: January 1990–January 2003In this review the names, structures and occurrence of all new drimanes and rearranged drimanes, which have been published between …
Web19 set 2024 · Chemical investigation of a coculture of the marine-derived fungi Beauveria felina KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of three new drimane-type sesquiterpenes, asperflavinoids B, D and E (2, 4, 5), and nine previously reported related compounds. The structures of these compounds were established using … WebAbstract. One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3–5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664.Their structures were determined by detailed analysis of spectroscopic data and by comparison with related …
WebThe HPLC-DAD method was developed and validated for the quantification of drimanes 1-3. The cytotoxic activity of these drimanes in human cancer cells, and the toxicological … Web10 apr 2024 · However, its most important feature from the organic synthesis viewpoint is its utility as a starting compound for the preparation of biologically active drimanes and nordrimanes. Among the biological activities of drimanic compounds are their antimicrobial, antifungal, growth inhibitors, molluscicide and gastroprotective properties [6,7,8,9].
Web1 apr 2014 · A novel spirocyclic drimane coupled by two drimane fragment building blocks 2 and a new drimane 1 were identified in mycelia and culture broth of Stachybotrys sp. …
WebJonathan Bisson, Jean-Luc Wolfender, Marc Litaudon, 2016, Analytical chemistry. boxpark careersWebSYNTHESIS OF POLYFUNCTIONAL DRIMANES FROM DRIM-7,9(11)-DIENE AND DRIM-8-EN-7-ONE Alexandru Ciocarlan,1,2 Carolina Edu,2 Andrei Biriiac,2 Lidia Lungu,2 Aculina Aricu,2 Michele D’Ambrosio,3 Sergiu ... box paris 16WebDrimanes and related bicyclic alkanes occur extensively in crude oils and ancient sediments, irrespective of geologic age and depositional environment. A mechanism is proposed for the formation of the bicyclic compounds in the subsurface by microbially mediated C-ring opening a {Delta}{sub 11(12)}-bacteriohopanetetrol during early … boxpark belfastWeb5 mar 2024 · Herein, we demonstrate that various drimanes are potent inhibitors of MCL-1 and BCL-xL, two proteins of the BCL-2 family that are overexpressed in various cancers, including lymphoid malignancies. Subtle changes in their structure significantly modified their activity on the target proteins. boxpark fanzone wembleyWeb4 mar 2024 · Drimanes are sesquiterpenes that have a bicyclic structure and are widespread in plants, liverworts, fungi and certain marine organisms (sponges) and are … gutheim nephrologyWeb10 mag 2024 · Seven new drimane-type sesquiterpenoids, namely the sporulositols A–D (1–4), 6-hydroxydiaporol (5), seco-sporulositol (6) and sporuloside (7) were isolated from the ethyl acetate extract of fermentation broth for a marine-derived fungus Paraconiothyrium sporulosum YK-03. Their structures were elucidated by analysis of extensive … box paper toysWeb28 apr 2024 · For classic drimanes, the core carbon skeleton may be constructed by a drimenol synthase to form the key precursor drimenol, which then undergoes multiple … boxpark halloween