Dexrazoxane used with doxorubicin
WebMar 16, 2024 · In children with cancer, giving dexrazoxane (Zinecard) before each dose of doxorubicin decreases the risk of treatment-related heart problems in adulthood, a new … WebThere is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, and cyclophosphamide (FAC) therapy interferes with the antitumor efficacy of the regimen, and this use is not recommended. ... The recommended dosage ratio of ZINECARD:doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD:50 mg/m2 ...
Dexrazoxane used with doxorubicin
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WebFeb 20, 2024 · This medicine is not given with your first dose of doxorubicin, but only after you've received prior doxorubicin doses up to a certain total amount. Dosing information. Usual Adult Dose for Cardiomyopathy Prophylaxis: Dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g. 500 mg/m2 dexrazoxane to 50 mg/m2 doxorubicin) WebThe recommended dexrazoxane : doxorubicin (or epirubicin) dosage ratio is 10 : 1 (e.g., if 40 mg/m 2 of doxorubicin is used, 400 mg/m 2 of dexrazoxane should be …
WebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a vein) infusion. When used to prevent tissue damage after extravasation, it is given once a day for 3 days, beginning no more than 6 hours after the leakage. WebDexrazoxane has been used in combination of doxorubicin to prevent heart failure. Schwartz et al used dexrazoxane as a cardioprotection to enable the use of higher cumulative dose of doxorubicin in children with osteosarcoma, cumulative dose of doxorubicin of 450 to 600 mg/m 2 was used. Out of 242 patients, only 5 developed …
WebJan 29, 2024 · Dexrazoxane protects against the cardiotoxic effects of anthracyclines, but in the USA and some European countries, its use had been restricted to adults with … WebAug 31, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration. Chemically, dexrazoxane is (S)-4,4'- (1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione. The structural formula is as follows:
Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more
WebDexrazoxane (Cardioxane, Zinecard, a cyclic derivative of edetic acid, is a site-specific cardioprotective agent that effectively protects against anthracycline-induced cardiac … list of virtual console games wiiWebAug 16, 2024 · Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It is in the class of medications known as cardioprotectants. ... The … list of vitamins and food sourcesWebUse of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. Cancer Prev Control 1999 ;3: 145 - 159 Medline list of virtual call centersWebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used for epirubicin, that is, institution of dexrazoxane when the cumulative dose of epirubicin reaches 550 mg/m2, as the recommended maximum cumulative dose in Canada is 1000 … immunity boost chicken soupWebJan 12, 2024 · The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an … list of visa free countries for nigeriansWebDexrazoxane is clinically used to reduce doxorubicin cardiotoxicity and anthracycline-induced extravasation injury. Dexrazoxane is a strong catalytic inhibitor of topoisomerase II. It can also undergo metabolism to form an iron-binding analog of EDTA. Dexrazoxane was originally thought to act by red … immunity booster drink shotsWebDexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be ... list of visionary tall buildings