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中国比较医学杂志_中国比较医学杂志杂志社-主页
WebApr 12, 2024 · The CYP24A1 gene encodes 1,25-hydroxyvitamin-D3-24-hydroxylase, a key enzyme responsible for the catabolism of active vitamin D (1,25-dihydroxyvitamin D3). Loss-of-function mutations in CYP24A1 … WebJun 16, 2024 · Fluconazole has been successfully reported to reduce calciuria in patients with CYP24A1 or SLC34A3 mutations, with no safety warnings. Thus, based on these case reports, we hypothesize that fluconazole is effective to decrease and normalize calciuria in patients with hypercalciuria and increased 1,25(OH)2D levels. The FLUCOLITH trial is a ... something inside me snapped
Contribution of CYP24A1 variants in coronary heart …
WebDec 10, 2024 · Background and objectives: CYP24A1 encodes a 24-hydroxylase involved in vitamin D catabolism, whose loss-of-function results in vitamin D-dependent hypercalcemia. Since the identification of CYP24A1 variants as a cause of idiopathic infantile hypercalcemia, a large body of literature has emerged indicating heterogeneity in … WebMar 1, 2012 · Mutations of the CYP24A1 gene, which encodes the 1,25-dihydroxyvitamin D-24-hydroxylase cytochrome P450, Cyp24A1, are predicted to result in elevated 1,25-dihydroxyvitamin D concentrations, hypercalcemia, hypercalciuria, nephrolithiasis, and bone disease. Treatment of hypercalcemia associated with CYP24A1 gene mutations has not … WebJan 22, 2024 · CYP24A1 protein expression in lung adenocarcinoma patients was reported up to 50 folds greater compared to healthy lung and significantly higher in poorly differentiated cancer types. The survival was proportional to the level of CYP24A1 expression (42% survival with high CYP24A1 expression versus 81% survival with low … something in orange