WebMar 21, 2024 · In an activation-tagging screen in Arabidopsis, two small and related proteins named BLUE LIGHT INHIBITOR OF CRYPTOCHROMES (BIC1 and BIC2) were identified . Overexpression of BICs disrupts cryptochrome dimerisation and the formation of nuclear photobodies, and transgenic plants resemble cry1 cry2 double mutants. WebRecent studies revealed distinct roles of these closely related homologs in clock output pathways. Isoform-selective control of CRY1 and CRY2 is critical for further understanding their redundant and distinct roles. KL001 was the first identified small-molecule CRY modulator that activates both CRY1 and CRY2.
Structural insights into photoactivation of plant Cryptochrome-2 - Nature
WebOct 22, 1999 · CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with PER1, PER2, and TIM. Thus, mammalian CRYs act as light … WebMar 10, 2015 · We demonstrate that genotoxic stress stimulates Cry1 phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 and shifting circadian clock time. DNA damage also increases Cry2 interaction with Fbxl3, destabilizing Cry2. Thus, genotoxic stress increases the … srey sopheat supermarket
CRY2 suppresses trophoblast migration and invasion in recurrent ...
WebAug 22, 2024 · The band intensities of CRY2 at B20′ were quantified and normalized against that of HSP90, then re-normalized to the value of sample D5B (i.e. CRY2 D5B /CRY2 D5B and CRY2 FR5B /CRY2 D5B) … WebOct 21, 2016 · Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) … WebMechanistically, miR-181d stabilized c-myc through directly targeting the 3'-UTRs of CRY2 and FBXL3, which subsequently increased the glucose consumption and the lactate production. Inhibition of c-myc via siRNA or small molecular inhibitor abolished the oncogenic effects of miR-181d on the growth and metastasis of CRC cells. sherman apartments concord mi