Cisplatin and sodium thiosulfate

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August undefined, 2024

WebThe chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced … WebSep 9, 2024 · Sodium thiosulfate is a type of medication used to treat cyanide poisoning and to help lessen the side effects from cisplatin. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

EMA Recommends Granting a Paediatric-Use Marketing...

WebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … WebFeb 14, 2024 · FDA approves sodium thiosulfate to reduce the risk of ototoxicity associated with cisplatin in pediatric patients with localized, non-metastatic solid tumors. … sharp pain in left hamstring

Cisplatin overdose: toxicities and management - PubMed

WebSep 21, 2024 · About PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce … WebMany cisplatin-protective agents have been evaluated: sodium thiosulfate , glutathione (GSH) , GSH ester , vitamin C , and sodium salicylate . However, to date, there are no methods that can completely prevent the loss of hair cells or the dysfunction of auditory nerves in cases of cisplatin-induced ototoxicity. WebSep 22, 2024 · On September 20, 2024, the U.S. Food and Drug Administration (FDA) approved the use of sodium thiosulfate (Pedmark®) to reduce the risk of ototoxicity associated with cisplatin in pediatric patients aged 1 month and older with localized, nonmetastatic solid tumors. sharp pain in left shoulder blade

Efficacy of Sodium Thiosulfate and Mannitol in Reducing …

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. WebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ... porotherm kp vario uniWebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium … porotherm labc

"WebApr 9, 2024 · In the COG ACCL0431, the hearing loss incidence rate was 28.6% in patients treated with sodium thiosulfate plus cisplatin compared with 56.4% in the cisplatin … " - Cisplatin and sodium thiosulfate

Cisplatin and sodium thiosulfate

WebSep 20, 2024 · On September 20, 2024, the Food and Drug Administration approved sodium thiosulfate (Pedmark, Fennec Pharmaceuticals Inc.) to reduce the risk of … WebApr 25, 2024 · Drug: Cisplatin Drug: Sodium thiosulfate Procedure: Cytoreductive surgery: Phase 2: Detailed Description: Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months. The treatment of choice for a localized primary or recurrent …

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WebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in-vivo models of myocardial IR as both preconditioning and post conditioning agent (Ravindran and Kurian 2024a ). WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... cisplatin was given as intraperitoneal infusion (16 ml/kg) over a 30 min. period through syringe pump using butterﬂy needle 23À3/4

WebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied … WebObjectives: To determine safety, feasibility, and preliminary activity of transtympanic injection of sodium thiosulfate (STS) against cisplatin-induced hearing loss (CIHL). …

WebApr 7, 2024 · On 30 March 2024, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending … WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the …

WebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced …

WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status porotherm lambdaWebcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … sharp pain in left breast when inhalingWebFeb 17, 2024 · Cisplatin extravasation, concentrated: Infants, Children, and Adolescents: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin extravasated; consider also injecting 1 mL of a 1/6 M (~4%) sodium thiosulfate solution as 0.1 mL subcutaneous injections (clockwise) into the area around … sharp pain in left side of chest below breastWebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied the disappearance of cisplatin and carboplatin in aqueous solutions of thiosulfate at 37 degrees C by means of liquid chromatography. sharp pain in left side of chest and backWebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in … sharp pain in left inner thighWebSodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species; In addition, sodium thiosulfate can enter cells through sodium sulfate cotransporter 2 … sharp pain in left arm above elbowWebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below … sharp pain in left breast when breathing